MolNFT v1 · #26400 · protein
D136N mutant of heme oxygenase from corynebacterium diphtheriae (hmuo)
1WNW: “D136N mutant of heme oxygenase from corynebacterium diphtheriae (hmuo)”. X-ray diffraction, 4 ligands (HEM, NA, SO4), 5 pockets (best druggability 0.75). MolNFT v1 #26400 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1WNW
- Type
- protein
- Length
- 624 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heme oxygenase
- EC
- 1.14.99.3
- UniProt
- P71119
- Ligands
- HEM, NA, SO4, IOD
- Pockets
- 5 · best druggability 0.75
Structure
x-ray diffraction · 3 distinct chains · 78% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heme oxygenase (EC 1.14.99.3) | protein | 208 | 78% helix, 0% strand | P71119 |
| B | Heme oxygenase (EC 1.14.99.3) | protein | 210 | 77% helix, 0% strand | P71119 |
| C | Heme oxygenase (EC 1.14.99.3) | protein | 206 | 79% helix, 0% strand | P71119 |
Ligands and binding sites
- HEM · Protoporphyrin IX containing Fe · ligand · 3 copies · chains A, B, C
- NA · Sodium ion · metal · 2 copies · chains B
- SO4 · Sulfate ion · ion · 12 copies · chains A, B, C
- IOD · Iodide ion · ion · 9 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 365 | 0.75 | 0.85 | 34 | IOD, HEM |
| 2 | 328 | 0.73 | 0.85 | 35 | IOD, HEM |
| 3 | 323 | 0.71 | 0.84 | 31 | HEM |
| 4 | 319 | 0.65 | 0.81 | 38 | SO4 |
| 5 | 418 | 0.64 | 0.78 | 35 | SO4 |
Interfaces
2 interfaces between chains.
- B–C · 790 Ų buried · 17 hydrogen bonds · protein-protein
- A–B · 601 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P71119
- Elsewhere: RCSB PDB 1WNW · PDBe 1WNW · UniProt P71119
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.