MolNFT v1 · #2621 · protein

Human CDC25A catalytic domain

1C25: “Human CDC25A catalytic domain”. X-ray diffraction, 2 pockets (best druggability 0.46). MolNFT v1 #2621 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1C25
Type: protein
Length: 161 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CDC25A
EC: 3.1.3.48
UniProt: P30304
Pockets: 2 · best druggability 0.46

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	CDC25A (EC 3.1.3.48)	protein	161	30% helix, 19% strand	P30304

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	119	0.46	0.78	27	empty
2	61	0.37	0.79	16	empty

Compared structures

1C25 · Human CDC25A catalytic domain · the same entry in another collection · chain A against A, TM-score 1.00
P30304 · AlphaFold monomer V2.0 prediction for M-phase inducer phosphatase 1 (P30304) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P30304
Elsewhere: RCSB PDB 1C25 · PDBe 1C25 · UniProt P30304

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