MolNFT v1 · #26043 · protein

Calcium free form of human peptidylarginine deiminase TYPE4 (PAD4)

1WD8 · Protein-arginine deiminase type IV: “Calcium free form of human peptidylarginine deiminase TYPE4 (PAD4)”. X-ray diffraction, 5 pockets (best druggability 0.75). MolNFT v1 #26043 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 1WD8
Type: protein
Length: 559 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein-arginine deiminase type IV
EC: 3.5.3.15
UniProt: Q9UM07
Pockets: 5 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 17% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein-arginine deiminase type IV (EC 3.5.3.15)	protein	559	17% helix, 38% strand	Q9UM07

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	470	0.75	0.83	56	empty
2	101	0.49	0.81	22	empty
3	51	0.39	0.81	17	empty
4	92	0.39	0.77	23	empty
5	110	0.38	0.75	29	empty

Compared structures

1WD8 · Calcium free form of human peptidylarginine deiminase type4 (PAD4) · the same entry in another collection · chain A against A, TM-score 1.00
Q9UM07 · AlphaFold monomer V2.0 prediction for protein-arginine deiminase type-4 (Q9UM07) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UM07
Elsewhere: RCSB PDB 1WD8 · PDBe 1WD8 · UniProt Q9UM07

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