MolNFT v1 · #25956 · protein

PP5 structure

1WAO · SERINE/THREONINE protein phosphatase 5: “PP5 structure”. X-ray diffraction, 1 ligand (MN), 17 pockets (best druggability 0.71). MolNFT v1 #25956 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1WAO
Type: protein
Length: 1,877 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE protein phosphatase 5
EC: 3.1.3.16
UniProt: P53041
Ligands: MN
Pockets: 17 · best druggability 0.71

Structure

x-ray diffraction · 3 distinct chains · 43% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
1, 3	SERINE/THREONINE protein phosphatase 5 (EC 3.1.3.16)	protein	471	42% helix, 14% strand	P53041
2	SERINE/THREONINE protein phosphatase 5 (EC 3.1.3.16)	protein	469	43% helix, 13% strand	P53041
4	SERINE/THREONINE protein phosphatase 5 (EC 3.1.3.16)	protein	466	43% helix, 13% strand	P53041

Ligands and binding sites

MN · Manganese (II) ion · metal · 8 copies · chains 1, 2, 3, 4

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

17 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	84	0.71	0.94	22	empty
2	179	0.66	0.86	28	empty
3	176	0.66	0.85	28	empty
4	261	0.59	0.79	33	empty
5	271	0.59	0.78	28	empty

Compared structures

1WAO · PP5 structure · the same entry in another collection · chain 1 against 1, TM-score 1.00
P53041 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase 5 (P53041) · a predicted model of the same protein · chain 4 against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P53041
Elsewhere: RCSB PDB 1WAO · PDBe 1WAO · UniProt P53041

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