MolNFT v1 · #25944 · protein

Crystal structure of the pas repeat region of the drosophila clock protein period

1WA9 · Period circadian protein: “Crystal structure of the pas repeat region of the drosophila clock protein period”. X-ray diffraction, 7 pockets (best druggability 0.67). MolNFT v1 #25944 on GenesisL1: 3D structure, binding sites and…

PDB: 1WA9
Type: protein
Length: 635 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Period circadian protein
UniProt: P07663
Pockets: 7 · best druggability 0.67

Structure

x-ray diffraction · 2 distinct chains · 29% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Period circadian protein	protein	317	27% helix, 26% strand	P07663
B	Period circadian protein	protein	318	31% helix, 24% strand	P07663

Pockets

7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	455	0.67	0.79	45	empty
2	127	0.49	0.79	19	empty
3	75	0.35	0.76	16	empty
4	99	0.34	0.73	17	empty
5	68	0.33	0.76	18	empty

Interfaces

1 interface between chains.

A–B · 2406 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

1WA9 · Crystal Structure of the PAS repeat region of the Drosophila clock protein PERIOD · the same entry in another collection · chain A against A, TM-score 1.00
P07663 · AlphaFold monomer V2.0 prediction for period circadian protein (P07663) · a predicted model of the same protein · chain B against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07663
Elsewhere: RCSB PDB 1WA9 · PDBe 1WA9 · UniProt P07663

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.