Research workbench

Crystal structure of the pas repeat region of the drosophila clock protein period

Analyse Crystal structure of the pas repeat region of the drosophila clock protein… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1WA9
Type: protein
Length: 635 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Period circadian protein
UniProt: P07663
Pockets: 7 · best druggability 0.67

Structure

x-ray diffraction · 2 distinct chains · 29% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Period circadian protein	protein	317	27% helix, 26% strand	P07663
B	Period circadian protein	protein	318	31% helix, 24% strand	P07663

Pockets

7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	455	0.67	0.79	45	empty
2	127	0.49	0.79	19	empty
3	75	0.35	0.76	16	empty
4	99	0.34	0.73	17	empty
5	68	0.33	0.76	18	empty

Interfaces

1 interface between chains.

A–B · 2406 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

1WA9 · Crystal Structure of the PAS repeat region of the Drosophila clock protein PERIOD · the same entry in another collection · chain A against A, TM-score 1.00
P07663 · AlphaFold monomer V2.0 prediction for period circadian protein (P07663) · a predicted model of the same protein · chain B against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07663
Elsewhere: RCSB PDB 1WA9 · PDBe 1WA9 · UniProt P07663

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.