MolNFT v1 · #25940 · protein
Structure of the CSE1:IMP-ALPHA:RANGTP complex
1WA5 · GTP-binding nuclear protein ran: “Structure of the CSE1:IMP-ALPHA:RANGTP complex”. X-ray diffraction, 2 ligands (GTP, MG), 20 pockets (best druggability 0.82). MolNFT v1 #25940 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 1WA5
- Type
- protein
- Length
- 1,586 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GTP-binding nuclear protein ran; SRP1 isoform 1; Importin alpha re-exporter
- UniProt
- P62825, A0A6A5Q590, P33307
- Ligands
- GTP, MG
- Pockets
- 20 · best druggability 0.82
Structure
x-ray diffraction · 3 distinct chains · 66% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | GTP-binding nuclear protein ran | protein | 170 | 29% helix, 27% strand | P62825 |
| B | SRP1 isoform 1 | protein | 466 | 69% helix, 0% strand | A0A6A5Q590 |
| C | Importin alpha re-exporter | protein | 950 | 72% helix, 1% strand | P33307 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 283 | 0.82 | 0.93 | 53 | GTP, MG |
| 2 | 382 | 0.80 | 0.89 | 50 | empty |
| 3 | 347 | 0.79 | 0.89 | 47 | empty |
| 4 | 100 | 0.66 | 0.91 | 20 | empty |
| 5 | 112 | 0.66 | 0.89 | 25 | empty |
Interfaces
3 interfaces between chains.
- B–C · 3003 Ų buried · 51 hydrogen bonds · protein-protein
- A–C · 2050 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 389 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 1WA5 · Structure of the Cse1:Imp-alpha:RanGTP complex · the same entry in another collection · chain A against A, TM-score 1.00
- P62825 · AlphaFold monomer V2.0 prediction for GTP-binding nuclear protein ran (P62825) · a predicted model of the same protein · chain A against A, TM-score 1.00
- P33307 · AlphaFold monomer V2.0 prediction for importin alpha re-exporter (P33307) · a predicted model of the same protein · chain C against A, TM-score 0.77
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62825
- Every structure of UniProt A0A6A5Q590
- Every structure of UniProt P33307
- Elsewhere: RCSB PDB 1WA5 · PDBe 1WA5 · UniProt P62825 · UniProt A0A6A5Q590 · UniProt P33307
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