MolNFT v1 · #25887 · protein
Enzymatic and structural characterisation of non peptide ligand cyclophilin complexes
1W8M · Peptidyl-prolyl cis-trans isomerase a: “Enzymatic and structural characterisation of non peptide ligand cyclophilin complexes”. X-ray diffraction, 1 ligand (E1P), 1 pocket (best druggability 0.34). MolNFT v1 #25887 on GenesisL1: 3D…
- PDB
- 1W8M
- Type
- protein
- Length
- 165 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peptidyl-prolyl cis-trans isomerase a
- EC
- 5.2.1.8
- UniProt
- P62937
- Ligands
- E1P
- Pockets
- 1 · best druggability 0.34
Structure
x-ray diffraction · 1 distinct chain · 14% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Peptidyl-prolyl cis-trans isomerase a (EC 5.2.1.8) | protein | 165 | 14% helix, 30% strand | P62937 |
Ligands and binding sites
- E1P · Ethyl oxo(piperidin-1-yl)acetate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 58 | 0.34 | 0.78 | 16 | empty |
Compared structures
- 1W8M · Enzymatic and Structural Characterisation of Non Peptide Ligand Cyclophilin Complexes · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62937
- Elsewhere: RCSB PDB 1W8M · PDBe 1W8M · UniProt P62937
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