MolNFT v1 · #25776 · protein

Ftsz dimer, GTP soak (M. jannaschii)

1W5B · Cell division protein ftsz homolog 1: “Ftsz dimer, GTP soak (M. jannaschii)”. X-ray diffraction, 1 ligand (GTP), 8 pockets (best druggability 0.81). MolNFT v1 #25776 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1W5B
Type: protein
Length: 668 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cell division protein ftsz homolog 1
UniProt: Q57816
Ligands: GTP
Pockets: 8 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 46% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cell division protein ftsz homolog 1	protein	333	46% helix, 24% strand	Q57816
B	Cell division protein ftsz homolog 1	protein	335	46% helix, 24% strand	Q57816

Ligands and binding sites

GTP · Guanosine-5'-triphosphate · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1010	0.81	0.82	69	GTP
2	240	0.59	0.80	37	empty
3	170	0.49	0.77	34	GTP
4	80	0.44	0.81	16	empty
5	93	0.42	0.78	17	empty

Interfaces

1 interface between chains.

A–B · 1115 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

1W5B · FtsZ dimer, GTP soak (M. jannaschii) · the same entry in another collection · chain A against A, TM-score 1.00
Q57816 · AlphaFold monomer V2.0 prediction for cell division protein ftsz 1 (Q57816) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q57816
Elsewhere: RCSB PDB 1W5B · PDBe 1W5B · UniProt Q57816

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.