MolNFT v1 · #25772 · protein
Structure of the bifunctional ispdf from campylobacter jejuni containing zn
1W57 · ISPD/ISPF bifunctional enzyme: “Structure of the bifunctional ispdf from campylobacter jejuni containing zn”. X-ray diffraction, 3 ligands (C5P, GPP, ZN), 3 pockets (best druggability 0.56). MolNFT v1 #25772 on GenesisL1: 3D…
- PDB
- 1W57
- Type
- protein
- Length
- 368 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ISPD/ISPF bifunctional enzyme
- EC
- 2.7.7.60, 4.6.1.12
- UniProt
- Q9PM68
- Ligands
- C5P, GPP, ZN
- Pockets
- 3 · best druggability 0.56
Structure
x-ray diffraction · 1 distinct chain · 31% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ISPD/ISPF bifunctional enzyme (EC 2.7.7.60, 4.6.1.12) | protein | 368 | 31% helix, 27% strand | Q9PM68 |
Ligands and binding sites
- C5P · Cytidine-5'-monophosphate · ligand · 2 copies · chains A
- GPP · Geranyl diphosphate · ligand · chains A
- ZN · Zinc ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 248 | 0.56 | 0.78 | 34 | C5P |
| 2 | 51 | 0.30 | 0.77 | 16 | empty |
| 3 | 65 | 0.27 | 0.73 | 14 | empty |
Compared structures
- 1W57 · Structure of the Bifunctional IspDF from Campylobacter jejuni containing Zn · the same entry in another collection · chain A against A, TM-score 1.00
- Q9PM68 · AlphaFold monomer V2.0 prediction for bifunctional enzyme ISPD/ISPF (Q9PM68) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9PM68
- Elsewhere: RCSB PDB 1W57 · PDBe 1W57 · UniProt Q9PM68
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