MolNFT v1 · #25727 · protein

The 2.1 angstroem resolution structure of annexin A8

1W3W: “The 2.1 angstroem resolution structure of annexin A8”. X-ray diffraction, 1 ligand (CA), 4 pockets (best druggability 0.56). MolNFT v1 #25727 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1W3W
Type: protein
Length: 311 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Annexin A8
UniProt: P13928
Ligands: CA
Pockets: 4 · best druggability 0.56

Structure

x-ray diffraction · 1 distinct chain · 73% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Annexin A8	protein	311	73% helix, 0% strand	P13928

Ligands and binding sites

CA · Calcium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	168	0.56	0.81	24	empty
2	79	0.49	0.83	19	empty
3	94	0.45	0.79	18	empty
4	81	0.39	0.77	14	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

1W3W · The 2.1 Angstroem resolution structure of annexin A8 · the same entry in another collection · chain A against A, TM-score 1.00
P13928 · AlphaFold monomer V2.0 prediction for annexin A8 (P13928) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P13928
Elsewhere: RCSB PDB 1W3W · PDBe 1W3W · UniProt P13928

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