MolNFT v1 · #25563 · protein
Structure of CDK2 complexed with pnu-181227
1VYZ · Cell division protein kinase 2: “Structure of CDK2 complexed with pnu-181227”. X-ray diffraction, 1 ligand (N5B), 1 pocket (best druggability 0.69). MolNFT v1 #25563 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1VYZ
- Type
- protein
- Length
- 279 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cell division protein kinase 2
- EC
- 2.7.1.37
- UniProt
- P24941
- Ligands
- N5B
- Pockets
- 1 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cell division protein kinase 2 (EC 2.7.1.37) | protein | 279 | 35% helix, 16% strand | P24941 |
Ligands and binding sites
- N5B · N-(5-cyclopropyl-1H-pyrazol-3-yl)benzamide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 235 | 0.69 | 0.85 | 32 | N5B |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P24941
- Elsewhere: RCSB PDB 1VYZ · PDBe 1VYZ · UniProt P24941
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.