MolNFT v1 · #25476 · protein
Symmetric sulfolobus solfataricus uracil phosphoribosyltransferase with bound prpp and GTP
1VST: “Symmetric sulfolobus solfataricus uracil phosphoribosyltransferase with bound prpp and GTP”. X-ray diffraction, 3 ligands (GTP, PRP, MG), 1 pocket (best druggability 0.60). MolNFT v1 #25476 on GenesisL1: 3D structure, binding sites…
- PDB
- 1VST
- Type
- protein
- Length
- 215 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uracil phosphoribosyltransferase
- EC
- 2.4.2.9
- UniProt
- Q980Q4
- Ligands
- GTP, PRP, MG
- Pockets
- 1 · best druggability 0.60
Structure
x-ray diffraction · 1 distinct chain · 33% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Uracil phosphoribosyltransferase (EC 2.4.2.9) | protein | 215 | 33% helix, 30% strand | Q980Q4 |
Ligands and binding sites
- GTP · Guanosine-5'-triphosphate · ligand · chains A
- PRP · 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose · ligand · chains A
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 257 | 0.60 | 0.79 | 33 | PRP |
Compared structures
- 1VST · Symmetric Sulfolobus solfataricus uracil phosphoribosyltransferase with bound PRPP and GTP · the same entry in another collection · chain A against A, TM-score 1.00
- Q980Q4 · AlphaFold monomer V2.0 prediction for uracil phosphoribosyltransferase (Q980Q4) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q980Q4
- Elsewhere: RCSB PDB 1VST · PDBe 1VST · UniProt Q980Q4
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