MolNFT v1 · #25225 · protein

Urokinase plasminogen activator B-chain-JT464 complex

1VJ9 · Plasminogen activator, urokinase: “Urokinase plasminogen activator B-chain-JT464 complex”. X-ray diffraction, 2 ligands (5IN, SO4), 1 pocket (best druggability 0.42). MolNFT v1 #25225 on GenesisL1: 3D structure, binding sites and…

PDB: 1VJ9
Type: protein
Length: 247 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Plasminogen activator, urokinase
EC: 3.4.21.73
UniProt: P00749
Ligands: 5IN, SO4
Pockets: 1 · best druggability 0.42

Structure

x-ray diffraction · 1 distinct chain · 11% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
U	Plasminogen activator, urokinase (EC 3.4.21.73)	protein	247	11% helix, 39% strand	P00749

Ligands and binding sites

5IN · N-(benzylsulfonyl)-L-seryl-N~1~-{4-[amino(imino)methyl]benzyl}-O-benzyl-L-serinamide · ligand · chains U
SO4 · Sulfate ion · ion · 2 copies · chains U

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	140	0.42	0.75	32	SO4, 5IN

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

1VJ9 · Urokinase Plasminogen Activator B-Chain-JT464 Complex · the same entry in another collection · chain U against U, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00749
Elsewhere: RCSB PDB 1VJ9 · PDBe 1VJ9 · UniProt P00749

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