MolNFT v1 · #25180 · protein

Crystal structure of putative holliday junction resolvase

1VHX: “Crystal structure of putative holliday junction resolvase”. X-ray diffraction, 3 pockets (best druggability 0.63). MolNFT v1 #25180 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1VHX
Type: protein
Length: 278 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative holliday junction resolvase
EC: 3.1.-.-
UniProt: O34634
Pockets: 3 · best druggability 0.63

Structure

x-ray diffraction · 2 distinct chains · 43% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Putative holliday junction resolvase (EC 3.1.-.-)	protein	140	44% helix, 28% strand	O34634
B	Putative holliday junction resolvase (EC 3.1.-.-)	protein	138	41% helix, 27% strand	O34634

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	354	0.63	0.79	41	empty
2	155	0.43	0.75	30	empty
3	86	0.32	0.73	23	empty

Interfaces

1 interface between chains.

A–B · 930 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 12 modified (engineered).

Compared structures

1VHX · Crystal structure of Putative Holliday junction resolvase · the same entry in another collection · chain A against A, TM-score 1.00
O34634 · AlphaFold monomer V2.0 prediction for putative pre-16S rRNA nuclease (O34634) · a predicted model of the same protein · chain B against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O34634
Elsewhere: RCSB PDB 1VHX · PDBe 1VHX · UniProt O34634

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