MolNFT v1 · #24996 · protein

Crystal structure of T.TH. HB8 CTP synthetase

1VCM: “Crystal structure of T.TH. HB8 CTP synthetase”. X-ray diffraction, 5 pockets (best druggability 0.55). MolNFT v1 #24996 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1VCM
Type: protein
Length: 531 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CTP synthetase
EC: 6.3.4.2
UniProt: Q5SIA8
Pockets: 5 · best druggability 0.55

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	CTP synthetase (EC 6.3.4.2)	protein	531	39% helix, 21% strand	Q5SIA8

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	265	0.55	0.77	43	empty
2	143	0.48	0.78	23	empty
3	81	0.47	0.82	16	empty
4	57	0.33	0.77	14	empty
5	57	0.29	0.75	13	empty

Compared structures

1VCM · Crystal Structure of T.th. HB8 CTP synthetase · the same entry in another collection · chain A against A, TM-score 1.00
Q5SIA8 · AlphaFold monomer V2.0 prediction for CTP synthase (Q5SIA8) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5SIA8
Elsewhere: RCSB PDB 1VCM · PDBe 1VCM · UniProt Q5SIA8

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