MolNFT v1 · #24861 · protein
The crystal structure of the minimal functional domain of the microtubule destabilizer KIF2C complexed with mg-amppnp
1V8K · Kinesin-like protein KIF2C: “The crystal structure of the minimal functional domain of the microtubule destabilizer KIF2C complexed with…”. X-ray diffraction, 2 ligands (ANP, MG), 4 pockets (best druggability 0.50). MolNFT v1 #24861…
- PDB
- 1V8K
- Type
- protein
- Length
- 332 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kinesin-like protein KIF2C
- UniProt
- Q922S8
- Ligands
- ANP, MG
- Pockets
- 4 · best druggability 0.50
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Kinesin-like protein KIF2C | protein | 332 | 36% helix, 29% strand | Q922S8 |
Ligands and binding sites
- ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · chains A
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 200 | 0.50 | 0.76 | 29 | empty |
| 2 | 138 | 0.44 | 0.76 | 25 | empty |
| 3 | 139 | 0.43 | 0.76 | 28 | MG, ANP |
| 4 | 89 | 0.40 | 0.77 | 15 | empty |
Compared structures
- 1V8K · The Crystal Structure of the Minimal Functional Domain of the Microtubule Destabilizer… · the same entry in another collection · chain A against A, TM-score 1.00
- Q922S8 · AlphaFold monomer V2.0 prediction for kinesin-like protein KIF2C (Q922S8) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q922S8
- Elsewhere: RCSB PDB 1V8K · PDBe 1V8K · UniProt Q922S8
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