MolNFT v1 · #24591 · protein
Glycogen phosphorylase B in complex with indirubin-5'-sulphonate
1UZU · Glycogen phosphorylase, muscle form: “Glycogen phosphorylase B in complex with indirubin-5'-sulphonate”. X-ray diffraction, 2 ligands (PLP, INR), 14 pockets (best druggability 0.85). MolNFT v1 #24591 on GenesisL1: 3D structure…
- PDB
- 1UZU
- Type
- protein
- Length
- 809 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glycogen phosphorylase, muscle form
- EC
- 2.4.1.1
- UniProt
- P00489
- Ligands
- PLP, INR
- Pockets
- 14 · best druggability 0.85
Structure
x-ray diffraction · 1 distinct chain · 52% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glycogen phosphorylase, muscle form (EC 2.4.1.1) | protein | 809 | 52% helix, 15% strand | P00489 |
Ligands and binding sites
- PLP · Pyridoxal-5'-phosphate · ligand · chains A
- INR · 2',3-dioxo-1,1',2',3-tetrahydro-2,3'-biindole-5'-sulfonic acid · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
14 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 283 | 0.85 | 0.96 | 61 | PLP |
| 2 | 150 | 0.79 | 0.96 | 38 | empty |
| 3 | 275 | 0.68 | 0.84 | 36 | empty |
| 4 | 118 | 0.53 | 0.82 | 18 | empty |
| 5 | 226 | 0.51 | 0.76 | 21 | empty |
Modifications
Observed in the structure: 1 cofactor (pyridoxal phosphate Schiff base).
Compared structures
- 1UZU · Glycogen Phosphorylase b in complex with indirubin-5'-sulphonate · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00489
- Elsewhere: RCSB PDB 1UZU · PDBe 1UZU · UniProt P00489
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