MolNFT v1 · #2445 · protein
Crystal structure of GDP-4-keto-6-deoxy-D-mannose EPIMERASE/REDUCTASE from escherichia COLI a key enzyme in the biosynthesis of GDP-L- fucose
1BWS · Protein (GDP-4-keto-6-deoxy-D-mannose EPIMERASE/REDUCTASE): “Crystal structure of GDP-4-keto-6-deoxy-D-mannose EPIMERASE/REDUCTASE from escherichia COLI a key enzyme in…”. X-ray diffraction, 1 ligand (NDP), 1 pocket (best…
- PDB
- 1BWS
- Type
- protein
- Length
- 314 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (GDP-4-keto-6-deoxy-D-mannose EPIMERASE/REDUCTASE)
- UniProt
- P32055
- Ligands
- NDP
- Pockets
- 1 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 45% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein (GDP-4-keto-6-deoxy-D-mannose EPIMERASE/REDUCTASE) | protein | 314 | 45% helix, 18% strand | P32055 |
Ligands and binding sites
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1056 | 0.79 | 0.80 | 85 | NDP |
Compared structures
- 1BWS · Crystal structure of GDP-4-keto-6-deoxy-D-mannose EPIMERASE/REDUCTASE from escherichia… · the same entry in another collection · chain A against A, TM-score 1.00
- P32055 · AlphaFold monomer V2.0 prediction for GDP-L-fucose synthase (P32055) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32055
- Elsewhere: RCSB PDB 1BWS · PDBe 1BWS · UniProt P32055
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