MolNFT v1 · #24426 · protein

Structure of an activated dictyostelium STAT in its DNA-unbound form

1UUS · STAT protein: “Structure of an activated dictyostelium STAT in its DNA-unbound form”. X-ray diffraction, 6 pockets (best druggability 0.64). MolNFT v1 #24426 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1UUS
Type: protein
Length: 465 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: STAT protein
UniProt: O00910
Pockets: 6 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	STAT protein	protein	465	38% helix, 20% strand	O00910

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	502	0.64	0.76	54	empty
2	186	0.45	0.74	21	empty
3	110	0.39	0.75	20	empty
4	82	0.36	0.76	21	empty
5	111	0.34	0.72	20	empty

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

1UUS · Structure of an activated Dictyostelium STAT in its DNA-unbound form · the same entry in another collection · chain A against A, TM-score 1.00
O00910 · AlphaFold monomer V2.0 prediction for signal transducer and activator of transcription a… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O00910
Elsewhere: RCSB PDB 1UUS · PDBe 1UUS · UniProt O00910

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