MolNFT v1 · #24254 · protein
Chicken calmodulin
1UP5: “Chicken calmodulin”. X-ray diffraction, 1 ligand (CA), 5 pockets (best druggability 0.46). MolNFT v1 #24254 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1UP5
- Type
- protein
- Length
- 293 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calmodulin
- UniProt
- P62149
- Ligands
- CA
- Pockets
- 5 · best druggability 0.46
Structure
x-ray diffraction · 2 distinct chains · 63% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calmodulin | protein | 145 | 64% helix, 4% strand | P62149 |
| B | Calmodulin | protein | 148 | 62% helix, 4% strand | P62149 |
Ligands and binding sites
- CA · Calcium ion · metal · 8 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 84 | 0.46 | 0.80 | 14 | empty |
| 2 | 76 | 0.45 | 0.80 | 12 | empty |
| 3 | 73 | 0.44 | 0.80 | 13 | empty |
| 4 | 75 | 0.42 | 0.78 | 13 | empty |
| 5 | 85 | 0.32 | 0.73 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 214 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (methylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62149
- Elsewhere: RCSB PDB 1UP5 · PDBe 1UP5 · UniProt P62149
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