MolNFT v1 · #24205 · protein
Complex of beta-clamp processivity factor and little finger domain of poliv
1UNN · DNA polymerase III beta subunit: “Complex of beta-clamp processivity factor and little finger domain of poliv”. X-ray diffraction, 1 ligand (SO4), 8 pockets (best druggability 0.51). MolNFT v1 #24205 on GenesisL1: 3D structure…
- PDB
- 1UNN
- Type
- protein
- Length
- 955 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA polymerase III beta subunit; DNA polymerase IV
- EC
- 2.7.7.7
- UniProt
- P00583, Q47155
- Ligands
- SO4
- Pockets
- 8 · best druggability 0.51
Structure
x-ray diffraction · 3 distinct chains · 26% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | DNA polymerase III beta subunit (EC 2.7.7.7) | protein | 366 | 22% helix, 42% strand | P00583 |
| C | DNA polymerase IV (EC 2.7.7.7) | protein | 111 | 33% helix, 35% strand | Q47155 |
| D | DNA polymerase IV (EC 2.7.7.7) | protein | 112 | 33% helix, 31% strand | Q47155 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 116 | 0.51 | 0.81 | 22 | empty |
| 2 | 97 | 0.46 | 0.80 | 18 | empty |
| 3 | 134 | 0.38 | 0.73 | 32 | empty |
| 4 | 58 | 0.33 | 0.77 | 14 | empty |
| 5 | 61 | 0.27 | 0.73 | 17 | empty |
Interfaces
5 interfaces between chains.
- A–B · 1291 Ų buried · 30 hydrogen bonds · protein-protein
- A–D · 1277 Ų buried · 21 hydrogen bonds · protein-protein
- B–C · 1219 Ų buried · 17 hydrogen bonds · protein-protein
- B–D · 341 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 341 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 1UNN · Complex of beta-clamp processivity factor and little finger domain of PolIV · the same entry in another collection · chain A against A, TM-score 1.00
- Q47155 · AlphaFold monomer V2.0 prediction for DNA polymerase IV (Q47155) · a predicted model of the same protein · chain C against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00583
- Every structure of UniProt Q47155
- Elsewhere: RCSB PDB 1UNN · PDBe 1UNN · UniProt P00583 · UniProt Q47155
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