MolNFT v1 · #24184 · protein
Crystal structure of yeast karyopherin (importin) alpha in complex with a NUP2P N-terminal fragment
1UN0 · Importin alpha subunit: “Crystal structure of yeast karyopherin (importin) alpha in complex with a NUP2P N-terminal fragment”. X-ray diffraction, 5 pockets (best druggability 0.81). MolNFT v1 #24184 on GenesisL1: 3D structure…
- PDB
- 1UN0
- Type
- protein
- Length
- 910 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin alpha subunit; Nucleoporin NUP2
- UniProt
- Q02821, P32499
- Pockets
- 5 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 69% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Importin alpha subunit | protein | 439 | 71% helix, 0% strand | Q02821 |
| C, D | Nucleoporin NUP2 | protein | 16 | 0% helix, 0% strand | P32499 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1109 | 0.81 | 0.83 | 87 | empty |
| 2 | 114 | 0.40 | 0.75 | 20 | empty |
| 3 | 109 | 0.37 | 0.74 | 19 | empty |
| 4 | 76 | 0.30 | 0.73 | 17 | empty |
| 5 | 61 | 0.28 | 0.74 | 16 | empty |
Interfaces
5 interfaces between chains.
- A–C · 1235 Ų buried · 23 hydrogen bonds · protein-protein
- B–D · 1174 Ų buried · 23 hydrogen bonds · protein-protein
- A–B · 1168 Ų buried · 12 hydrogen bonds · protein-protein
- A–D · 113 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 105 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1UN0 · Crystal Structure of Yeast Karyopherin (Importin) alpha in complex with a Nup2p… · the same entry in another collection · chain A against A, TM-score 1.00
- Q02821 · AlphaFold monomer V2.0 prediction for importin subunit alpha (Q02821) · a predicted model of the same protein · chain A against A, TM-score 0.95
- P32499 · AlphaFold monomer V2.0 prediction for nucleoporin NUP2 (P32499) · a predicted model of the same protein · chain C against A, TM-score 0.20
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q02821
- Every structure of UniProt P32499
- Elsewhere: RCSB PDB 1UN0 · PDBe 1UN0 · UniProt Q02821 · UniProt P32499
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