MolNFT v1 · #24067 · protein
Vhs domain of human GGA1 complexed with C-terminal peptide from bace
1UJJ · ADP-ribosylation factor binding protein GGA1: “Vhs domain of human GGA1 complexed with C-terminal peptide from bace”. X-ray diffraction, 2 pockets (best druggability 0.51). MolNFT v1 #24067 on GenesisL1: 3D structure, binding sites…
- PDB
- 1UJJ
- Type
- protein
- Length
- 287 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ADP-ribosylation factor binding protein GGA1; C-terminal peptide from beta-secretase
- EC
- 3.4.23.-
- UniProt
- Q9UJY5, P56817
- Pockets
- 2 · best druggability 0.51
Structure
x-ray diffraction · 2 distinct chains · 65% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | ADP-ribosylation factor binding protein GGA1 | protein | 140 | 69% helix, 1% strand | Q9UJY5 |
| C | C-terminal peptide from beta-secretase (EC 3.4.23.-) | protein | 7 | 0% helix, 0% strand | P56817 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 196 | 0.51 | 0.77 | 23 | empty |
| 2 | 156 | 0.50 | 0.78 | 25 | empty |
Interfaces
2 interfaces between chains.
- A–C · 467 Ų buried · 12 hydrogen bonds · protein-protein
- A–B · 412 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 1UJJ · VHS domain of human GGA1 complexed with C-terminal peptide from BACE · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UJY5 · AlphaFold monomer V2.0 prediction for ADP-ribosylation factor-binding protein GGA1… · a predicted model of the same protein · chain A against A, TM-score 0.98
- P56817 · AlphaFold monomer V2.0 prediction for beta-secretase 1 (P56817) · a predicted model of the same protein · chain C against A, TM-score 0.50
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UJY5
- Every structure of UniProt P56817
- Elsewhere: RCSB PDB 1UJJ · PDBe 1UJJ · UniProt Q9UJY5 · UniProt P56817
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