MolNFT v1 · #24050 · protein

Crystal structures of the liganded and unliganded nickel binding protein nika from escherichia COLI (nickel unliganded form)

1UIU · Nickel-binding periplasmic protein: “Crystal structures of the liganded and unliganded nickel binding protein nika from escherichia COLI (nickel…”. X-ray diffraction, 13 pockets (best druggability 0.76). MolNFT v1 #24050 on…

PDB: 1UIU
Type: protein
Length: 992 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nickel-binding periplasmic protein
UniProt: P33590
Pockets: 13 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Nickel-binding periplasmic protein	protein	496	31% helix, 25% strand	P33590

Pockets

13 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	602	0.76	0.82	79	empty
2	140	0.69	0.90	26	empty
3	336	0.67	0.81	50	empty
4	147	0.66	0.87	30	empty
5	633	0.66	0.76	71	empty

Interfaces

1 interface between chains.

A–B · 693 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

1UIU · Crystal structures of the liganded and unliganded nickel binding protein NikA from… · the same entry in another collection · chain A against A, TM-score 1.00
P33590 · AlphaFold monomer V2.0 prediction for nickel-binding periplasmic protein (P33590) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P33590
Elsewhere: RCSB PDB 1UIU · PDBe 1UIU · UniProt P33590

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