MolNFT v1 · #23972 · protein
Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: protein mimicry of DNA
1UGH · Protein (uracil-DNA glycosylase): “Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: protein mimicry of DNA”. X-ray diffraction, 5 pockets (best druggability 0.72). MolNFT v1 #23972 on GenesisL1…
- PDB
- 1UGH
- Type
- protein
- Length
- 305 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (uracil-DNA glycosylase); Protein (uracil-DNA glycosylase inhibitor)
- EC
- 3.2.2.3
- UniProt
- P13051
- Pockets
- 5 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E | Protein (uracil-DNA glycosylase) (EC 3.2.2.3) | protein | 223 | 40% helix, 11% strand | P13051 |
| I | Protein (uracil-DNA glycosylase inhibitor) | protein | 82 | 21% helix, 40% strand | — |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 65 | 0.72 | 0.98 | 27 | empty |
| 2 | 79 | 0.40 | 0.78 | 19 | empty |
| 3 | 70 | 0.38 | 0.78 | 12 | empty |
| 4 | 105 | 0.37 | 0.74 | 23 | empty |
| 5 | 60 | 0.28 | 0.74 | 15 | empty |
Interfaces
1 interface between chains.
- E–I · 1149 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 1UGH · Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor… · the same entry in another collection · chain E against E, TM-score 1.00
- P13051 · AlphaFold monomer V2.0 prediction for uracil-DNA glycosylase (P13051) · a predicted model of the same protein · chain E against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13051
- Elsewhere: RCSB PDB 1UGH · PDBe 1UGH · UniProt P13051
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