MolNFT v1 · #23887 · protein
Crystal structure of human uridine-cytidine kinase 2 complexed with a feedback-inhibitor, CTP
1UDW: “Crystal structure of human uridine-cytidine kinase 2 complexed with a feedback-inhibitor, CTP”. X-ray diffraction, 1 ligand (CTP), 4 pockets (best druggability 0.65). MolNFT v1 #23887 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1UDW
- Type
- protein
- Length
- 413 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uridine-cytidine kinase 2
- EC
- 2.7.1.48
- UniProt
- Q9BZX2
- Ligands
- CTP
- Pockets
- 4 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 49% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Uridine-cytidine kinase 2 (EC 2.7.1.48) | protein | 204 | 49% helix, 22% strand | Q9BZX2 |
| B | Uridine-cytidine kinase 2 (EC 2.7.1.48) | protein | 209 | 49% helix, 22% strand | Q9BZX2 |
Ligands and binding sites
- CTP · Cytidine-5'-triphosphate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 160 | 0.65 | 0.86 | 29 | CTP |
| 2 | 177 | 0.65 | 0.86 | 31 | CTP |
| 3 | 340 | 0.61 | 0.78 | 47 | empty |
| 4 | 83 | 0.32 | 0.73 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 356 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 1UDW · Crystal structure of human uridine-cytidine kinase 2 complexed with a feedback-inhibitor… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9BZX2 · AlphaFold monomer V2.0 prediction for uridine-cytidine kinase 2 (Q9BZX2) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9BZX2
- Elsewhere: RCSB PDB 1UDW · PDBe 1UDW · UniProt Q9BZX2
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.