MolNFT v1 · #23858 · protein

Crystal structure of the C-terminal 10-kda subdomain of HSC70

1UD0 · 70 kda heat-shock-like protein: “Crystal structure of the C-terminal 10-kda subdomain of HSC70”. X-ray diffraction, 1 ligand (NA), 2 pockets (best druggability 0.48). MolNFT v1 #23858 on GenesisL1: 3D structure, binding sites and…

PDB: 1UD0
Type: protein
Length: 332 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 70 kda heat-shock-like protein
UniProt: P63018
Ligands: NA
Pockets: 2 · best druggability 0.48

Structure

x-ray diffraction · 4 distinct chains · 74% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	70 kda heat-shock-like protein	protein	84	76% helix, 0% strand	P63018
B	70 kda heat-shock-like protein	protein	82	66% helix, 0% strand	P63018
C	70 kda heat-shock-like protein	protein	88	73% helix, 0% strand	P63018
D	70 kda heat-shock-like protein	protein	78	82% helix, 0% strand	P63018

Ligands and binding sites

NA · Sodium ion · metal · 3 copies · chains B, D, A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	139	0.48	0.78	28	empty
2	67	0.36	0.77	15	empty

Interfaces

4 interfaces between chains.

C–D · 1973 Å² buried · 11 hydrogen bonds · protein-protein
A–B · 1799 Å² buried · 7 hydrogen bonds · protein-protein
A–C · 495 Å² buried · 4 hydrogen bonds · protein-protein
A–D · 389 Å² buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 12 modified (engineered).

Compared structures

1UD0 · CRYSTAL STRUCTURE OF THE C-TERMINAL 10-kDA SUBDOMAIN OF HSC70 · the same entry in another collection · chain D against D, TM-score 1.00
P63018 · AlphaFold monomer V2.0 prediction for heat shock cognate 71 kda protein (P63018) · a predicted model of the same protein · chain D against A, TM-score 0.61

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P63018
Elsewhere: RCSB PDB 1UD0 · PDBe 1UD0 · UniProt P63018

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