Research workbench
Crystal structure of the C-terminal 10-kda subdomain of HSC70
Analyse Crystal structure of the C-terminal 10-kda subdomain of HSC70 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1UD0
- Type
- protein
- Length
- 332 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 70 kda heat-shock-like protein
- UniProt
- P63018
- Ligands
- NA
- Pockets
- 2 · best druggability 0.48
Structure
x-ray diffraction · 4 distinct chains · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 70 kda heat-shock-like protein | protein | 84 | 76% helix, 0% strand | P63018 |
| B | 70 kda heat-shock-like protein | protein | 82 | 66% helix, 0% strand | P63018 |
| C | 70 kda heat-shock-like protein | protein | 88 | 73% helix, 0% strand | P63018 |
| D | 70 kda heat-shock-like protein | protein | 78 | 82% helix, 0% strand | P63018 |
Ligands and binding sites
- NA · Sodium ion · metal · 3 copies · chains B, D, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 139 | 0.48 | 0.78 | 28 | empty |
| 2 | 67 | 0.36 | 0.77 | 15 | empty |
Interfaces
4 interfaces between chains.
- C–D · 1973 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 1799 Ų buried · 7 hydrogen bonds · protein-protein
- A–C · 495 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 389 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 modified (engineered).
Compared structures
- 1UD0 · CRYSTAL STRUCTURE OF THE C-TERMINAL 10-kDA SUBDOMAIN OF HSC70 · the same entry in another collection · chain D against D, TM-score 1.00
- P63018 · AlphaFold monomer V2.0 prediction for heat shock cognate 71 kda protein (P63018) · a predicted model of the same protein · chain D against A, TM-score 0.61
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63018
- Elsewhere: RCSB PDB 1UD0 · PDBe 1UD0 · UniProt P63018
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