MolNFT v1 · #23613 · protein
Structure of the D23A mutant of the nuclear transport carrier NTF2
1U5O · Nuclear transport factor 2: “Structure of the D23A mutant of the nuclear transport carrier NTF2”. X-ray diffraction, 3 pockets (best druggability 0.53). MolNFT v1 #23613 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1U5O
- Type
- protein
- Length
- 246 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nuclear transport factor 2
- UniProt
- P61972
- Pockets
- 3 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 28% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nuclear transport factor 2 | protein | 125 | 29% helix, 48% strand | P61972 |
| B | Nuclear transport factor 2 | protein | 121 | 28% helix, 47% strand | P61972 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 266 | 0.53 | 0.76 | 30 | empty |
| 2 | 96 | 0.50 | 0.81 | 19 | empty |
| 3 | 57 | 0.39 | 0.79 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1323 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 1U5O · Structure of the D23A mutant of the nuclear transport carrier NTF2 · the same entry in another collection · chain A against A, TM-score 1.00
- P61972 · AlphaFold monomer V2.0 prediction for nuclear transport factor 2 (P61972) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61972
- Elsewhere: RCSB PDB 1U5O · PDBe 1U5O · UniProt P61972
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