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Structure of the D23A mutant of the nuclear transport carrier NTF2

Analyse Structure of the D23A mutant of the nuclear transport carrier NTF2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1U5O
Type: protein
Length: 246 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nuclear transport factor 2
UniProt: P61972
Pockets: 3 · best druggability 0.53

Structure

x-ray diffraction · 2 distinct chains · 28% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nuclear transport factor 2	protein	125	29% helix, 48% strand	P61972
B	Nuclear transport factor 2	protein	121	28% helix, 47% strand	P61972

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	266	0.53	0.76	30	empty
2	96	0.50	0.81	19	empty
3	57	0.39	0.79	14	empty

Interfaces

1 interface between chains.

A–B · 1323 Å² buried · 18 hydrogen bonds · protein-protein

Compared structures

1U5O · Structure of the D23A mutant of the nuclear transport carrier NTF2 · the same entry in another collection · chain A against A, TM-score 1.00
P61972 · AlphaFold monomer V2.0 prediction for nuclear transport factor 2 (P61972) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P61972
Elsewhere: RCSB PDB 1U5O · PDBe 1U5O · UniProt P61972

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