MolNFT v1 · #23590 · protein

Crystal structure of repeats 15, 16 and 17 of chicken brain alpha spectrin

1U4Q · Spectrin alpha chain, brain: “Crystal structure of repeats 15, 16 and 17 of chicken brain alpha spectrin”. X-ray diffraction, 5 pockets (best druggability 0.70). MolNFT v1 #23590 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 1U4Q
Type: protein
Length: 635 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Spectrin alpha chain, brain
UniProt: P07751
Pockets: 5 · best druggability 0.70

Structure

x-ray diffraction · 2 distinct chains · 85% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Spectrin alpha chain, brain	protein	318	85% helix, 0% strand	P07751
B	Spectrin alpha chain, brain	protein	317	85% helix, 0% strand	P07751

Pockets

5 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	425	0.70	0.81	53	empty
2	416	0.69	0.81	47	empty
3	351	0.69	0.82	48	empty
4	296	0.55	0.76	34	empty
5	276	0.54	0.76	29	empty

Interfaces

1 interface between chains.

A–B · 1817 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

1U4Q · Crystal Structure of Repeats 15, 16 and 17 of Chicken Brain Alpha Spectrin · the same entry in another collection · chain A against A, TM-score 1.00
P07751 · AlphaFold monomer V2.0 prediction for spectrin alpha chain, non- erythrocytic 1 (P07751) · a predicted model of the same protein · chain A against A, TM-score 0.80

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07751
Elsewhere: RCSB PDB 1U4Q · PDBe 1U4Q · UniProt P07751

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