MolNFT v1 · #23488 · protein + DNA

Crystal structure of UP1 complexed with D(TTAGGGTTA(DI)GG); a human telomeric repeat containing inosine

1U1Q · 5'-D(*TP*AP*GP*GP*GP*TP*TP*AP*(OIP)*GP*G)-3': “Crystal structure of UP1 complexed with D(TTAGGGTTA(DI)GG); a human telomeric repeat containing inosine”. X-ray diffraction, 1 pocket (best druggability 0.54). MolNFT v1 #23488 on…

PDB: 1U1Q
Type: protein + DNA
Length: 194 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 5'-D(*TP*AP*GP*GP*GP*TP*TP*AP*(OIP)*GP*G)-3'; Heterogeneous nuclear ribonucleoprotein A1
UniProt: P09651
Pockets: 1 · best druggability 0.54

Structure

x-ray diffraction · 2 distinct chains · 28% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	5'-D(TPAPGPGPGPTPTPAP(OIP)GP*G)-3'	dna	11	—	—
A	Heterogeneous nuclear ribonucleoprotein A1	protein	183	28% helix, 34% strand	P09651

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	209	0.54	0.78	26	empty

Interfaces

1 interface between chains.

B–A · 808 Å² buried · 25 hydrogen bonds · protein-nucleic

Compared structures

1U1Q · Crystal Structure of UP1 Complexed With d(TTAGGGTTA(DI)GG); A Human Telomeric Repeat… · the same entry in another collection · chain B against B, TM-score 1.00
P09651 · AlphaFold monomer V2.0 prediction for heterogeneous nuclear ribonucleoprotein A1 (P09651) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P09651
Elsewhere: RCSB PDB 1U1Q · PDBe 1U1Q · UniProt P09651

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