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MolNFT v1 · #23485 · protein + DNA

Crystal structure of UP1 complexed with D(TTAGGGTTA (prn) gg); a human telomeric repeat containing nebularine

1U1N · 5'-D(*TP*AP*GP*GP*GP*TP*TP*AP*(PRN)P*GP*G)-3': “Crystal structure of UP1 complexed with D(TTAGGGTTA (prn) gg); a human telomeric repeat containing nebularine”. X-ray diffraction, 1 pocket (best druggability 0.55). MolNFT v1 #23485…

PDB
1U1N
Type
protein + DNA
Length
194 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
5'-D(*TP*AP*GP*GP*GP*TP*TP*AP*(PRN)P*GP*G)-3'; Heterogeneous nuclear ribonucleoprotein A1
UniProt
P09651
Pockets
1 · best druggability 0.55

Structure

x-ray diffraction · 2 distinct chains · 29% helix, 35% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
B5'-D(*TP*AP*GP*GP*GP*TP*TP*AP*(PRN)P*GP*G)-3'dna11——
AHeterogeneous nuclear ribonucleoprotein A1protein18329% helix, 35% strandP09651

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
12070.550.7929empty

Interfaces

1 interface between chains.

  • B–A · 789 Ų buried · 20 hydrogen bonds · protein-nucleic

Modifications

Observed in the structure: 1 modified (nucleotide modification).

Compared structures

  • 1U1N · Crystal Structure of UP1 Complexed With d(TTAGGGTTA (PRN)GG); A Human Telomeric Repeat… · the same entry in another collection · chain B against B, TM-score 1.00
  • P09651 · AlphaFold monomer V2.0 prediction for heterogeneous nuclear ribonucleoprotein A1 (P09651) · a predicted model of the same protein · chain A against A, TM-score 0.98

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