MolNFT v1 · #23405 · protein
Crystal structure of native PHOSPHOGLUCOSE/PHOSPHOMANNOSE isomerase from pyrobaculum aerophilum
1TZB · Glucose-6-phosphate isomerase, conjectural: “Crystal structure of native PHOSPHOGLUCOSE/PHOSPHOMANNOSE isomerase from pyrobaculum aerophilum”. X-ray diffraction, 1 ligand (SO4), 7 pockets (best druggability 0.86). MolNFT v1 #23405…
- PDB
- 1TZB
- Type
- protein
- Length
- 601 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glucose-6-phosphate isomerase, conjectural
- EC
- 5.3.1.9, 5.3.1.8
- UniProt
- Q8ZWV0
- Ligands
- SO4
- Pockets
- 7 · best druggability 0.86
Structure
x-ray diffraction · 2 distinct chains · 48% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glucose-6-phosphate isomerase, conjectural (EC 5.3.1.9, 5.3.1.8) | protein | 301 | 47% helix, 17% strand | Q8ZWV0 |
| B | Glucose-6-phosphate isomerase, conjectural (EC 5.3.1.9, 5.3.1.8) | protein | 300 | 48% helix, 17% strand | Q8ZWV0 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 595 | 0.86 | 0.91 | 62 | GOL |
| 2 | 116 | 0.52 | 0.82 | 20 | SO4 |
| 3 | 117 | 0.48 | 0.80 | 20 | SO4 |
| 4 | 115 | 0.37 | 0.74 | 24 | empty |
| 5 | 57 | 0.34 | 0.77 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 3196 Ų buried · 79 hydrogen bonds · protein-protein
Compared structures
- 1TZB · Crystal structure of native phosphoglucose/phosphomannose isomerase from Pyrobaculum… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8ZWV0 · AlphaFold monomer V2.0 prediction for bifunctional PHOSPHOGLUCOSE/PHOSPHOMANNOSE… · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8ZWV0
- Elsewhere: RCSB PDB 1TZB · PDBe 1TZB · UniProt Q8ZWV0
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