MolNFT v1 · #23380 · protein
The structure of a complex of hexameric insulin and 4'- hydroxyacetanilide
1TYM: “The structure of a complex of hexameric insulin and 4'- hydroxyacetanilide”. X-ray diffraction, 3 ligands (TYL, ZN, CL). MolNFT v1 #23380 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1TYM
- Type
- protein
- Length
- 98 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin
- UniProt
- P01308
- Ligands
- TYL, ZN, CL
Structure
x-ray diffraction · 3 distinct chains · 61% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Insulin | protein | 21 | 67% helix, 5% strand | P01308 |
| B | Insulin | protein | 29 | 48% helix, 10% strand | P01308 |
| D | Insulin | protein | 27 | 70% helix, 11% strand | P01308 |
Ligands and binding sites
- TYL · N-(4-hydroxyphenyl)acetamide (tylenol) · ligand · chains C, D
- ZN · Zinc ion · metal · 2 copies · chains B, D
- CL · Chloride ion · ion · chains D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
5 interfaces between chains.
- A–B · 787 Ų buried · 10 hydrogen bonds · protein-protein
- B–D · 652 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 603 Ų buried · 5 hydrogen bonds · protein-protein
- A–D · 60 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 33 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 1TYM · The structure of a complex of hexameric insulin and 4'-hydroxyacetanilide · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 1TYM · PDBe 1TYM · UniProt P01308
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