MolNFT v1 · #23314 · protein
Crystal structure of the putative copper homeostasis protein (cutc) from shigella flexneri, northeast structural genomics target SFR33
1TWD · Copper homeostasis protein cutc: “Crystal structure of the putative copper homeostasis protein (cutc) from shigella flexneri, northeast…”. X-ray diffraction, 3 pockets (best druggability 0.74). MolNFT v1 #23314 on GenesisL1: 3D…
- PDB
- 1TWD
- Type
- protein
- Length
- 469 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Copper homeostasis protein cutc
- UniProt
- P67825
- Pockets
- 3 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Copper homeostasis protein cutc | protein | 234 | 41% helix, 20% strand | P67825 |
| B | Copper homeostasis protein cutc | protein | 235 | 41% helix, 20% strand | P67825 |
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 288 | 0.74 | 0.87 | 73 | empty |
| 2 | 278 | 0.55 | 0.76 | 40 | empty |
| 3 | 236 | 0.52 | 0.76 | 32 | empty |
Interfaces
1 interface between chains.
- A–B · 1900 Ų buried · 41 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 18 modified (engineered).
Compared structures
- 1TWD · Crystal Structure of the Putative Copper Homeostasis Protein (CutC) from Shigella… · the same entry in another collection · chain A against A, TM-score 1.00
- P67825 · AlphaFold monomer V2.0 prediction for copper homeostasis protein cutc (P67825) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P67825
- Elsewhere: RCSB PDB 1TWD · PDBe 1TWD · UniProt P67825
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