Research workbench
Crystal structure of the putative copper homeostasis protein (cutc) from shigella flexneri, northeast structural genomics target SFR33
Analyse Crystal structure of the putative copper homeostasis protein (cutc) from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1TWD
- Type
- protein
- Length
- 469 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Copper homeostasis protein cutc
- UniProt
- P67825
- Pockets
- 3 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Copper homeostasis protein cutc | protein | 234 | 41% helix, 20% strand | P67825 |
| B | Copper homeostasis protein cutc | protein | 235 | 41% helix, 20% strand | P67825 |
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 288 | 0.74 | 0.87 | 73 | empty |
| 2 | 278 | 0.55 | 0.76 | 40 | empty |
| 3 | 236 | 0.52 | 0.76 | 32 | empty |
Interfaces
1 interface between chains.
- A–B · 1900 Ų buried · 41 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 18 modified (engineered).
Compared structures
- 1TWD · Crystal Structure of the Putative Copper Homeostasis Protein (CutC) from Shigella… · the same entry in another collection · chain A against A, TM-score 1.00
- P67825 · AlphaFold monomer V2.0 prediction for copper homeostasis protein cutc (P67825) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P67825
- Elsewhere: RCSB PDB 1TWD · PDBe 1TWD · UniProt P67825
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