MolNFT v1 · #23249 · protein

Intact elongation factor tu in complex with GDP

1TUI: “Intact elongation factor tu in complex with GDP”. X-ray diffraction, 2 ligands (GDP, MG), 10 pockets (best druggability 0.55). MolNFT v1 #23249 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1TUI
Type: protein
Length: 1,191 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Elongation factor tu
UniProt: Q01698
Ligands: GDP, MG
Pockets: 10 · best druggability 0.55

Structure

x-ray diffraction · 1 distinct chain · 23% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Elongation factor tu	protein	397	23% helix, 35% strand	Q01698

Ligands and binding sites

GDP · Guanosine-5'-diphosphate · ligand · 3 copies · chains A, B, C
MG · Magnesium ion · metal · 3 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

10 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	275	0.55	0.77	26	empty
2	203	0.51	0.77	22	empty
3	155	0.50	0.78	38	empty
4	240	0.48	0.74	38	empty
5	132	0.46	0.78	23	empty

Interfaces

2 interfaces between chains.

B–C · 424 Å² buried · 8 hydrogen bonds · protein-protein
A–B · 341 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

1TUI · Intact elongation factor tu in complex with GDP · the same entry in another collection · chain A against A, TM-score 1.00
Q01698 · AlphaFold monomer V2.0 prediction for elongation factor tu (Q01698) · a predicted model of the same protein · chain C against A, TM-score 0.61

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q01698
Elsewhere: RCSB PDB 1TUI · PDBe 1TUI · UniProt Q01698

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.