MolNFT v1 · #23109 · protein
Crystal structure of IIGP1: a paradigm for interferon inducible P47 resistance gtpases
1TQ6 · Interferon-inducible GTPase: “Crystal structure of IIGP1: a paradigm for interferon inducible P47 resistance gtpases”. X-ray diffraction, 2 ligands (GNP, MG), 4 pockets (best druggability 0.71). MolNFT v1 #23109 on GenesisL1: 3D…
- PDB
- 1TQ6
- Type
- protein
- Length
- 402 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interferon-inducible GTPase
- UniProt
- Q9QZ85
- Ligands
- GNP, MG
- Pockets
- 4 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 56% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interferon-inducible GTPase | protein | 402 | 56% helix, 8% strand | Q9QZ85 |
Ligands and binding sites
- GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · chains A
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 522 | 0.71 | 0.80 | 48 | empty |
| 2 | 53 | 0.37 | 0.80 | 22 | GNP |
| 3 | 85 | 0.33 | 0.74 | 19 | empty |
| 4 | 57 | 0.29 | 0.75 | 16 | empty |
Compared structures
- 1TQ6 · Crystal Structure of IIGP1: a paradigm for interferon inducible p47 resistance GTPases · the same entry in another collection · chain A against A, TM-score 1.00
- Q9QZ85 · AlphaFold monomer V2.0 prediction for interferon-inducible GTPase 1 (Q9QZ85) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9QZ85
- Elsewhere: RCSB PDB 1TQ6 · PDBe 1TQ6 · UniProt Q9QZ85
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.