MolNFT v1 · #23102 · protein
Crystal structure of IIGP1: a paradigm for interferon inducible P47 resistance gtpases
1TPZ · Interferon-inducible GTPase: “Crystal structure of IIGP1: a paradigm for interferon inducible P47 resistance gtpases”. X-ray diffraction, 2 ligands (GDP, MG), 15 pockets (best druggability 0.70). MolNFT v1 #23102 on GenesisL1: 3D…
- PDB
- 1TPZ
- Type
- protein
- Length
- 787 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interferon-inducible GTPase
- UniProt
- Q9QZ85
- Ligands
- GDP, MG
- Pockets
- 15 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 55% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interferon-inducible GTPase | protein | 395 | 55% helix, 8% strand | Q9QZ85 |
| B | Interferon-inducible GTPase | protein | 392 | 55% helix, 9% strand | Q9QZ85 |
Ligands and binding sites
- GDP · Guanosine-5'-diphosphate · ligand · 2 copies · chains A, B
- MG · Magnesium ion · metal · 2 copies · chains A, B
- EDO · 1,2-ethanediol · additive · chains B
- MPD · (4S)-2-methyl-2,4-pentanediol · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
15 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 550 | 0.70 | 0.79 | 45 | empty |
| 2 | 502 | 0.69 | 0.79 | 46 | EDO, MPD |
| 3 | 229 | 0.58 | 0.79 | 38 | MG, GDP |
| 4 | 200 | 0.56 | 0.80 | 32 | MG, GDP |
| 5 | 107 | 0.44 | 0.78 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 1147 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 1TPZ · Crystal Structure of IIGP1: a paradigm for interferon inducible p47 resistance GTPases · the same entry in another collection · chain A against A, TM-score 1.00
- Q9QZ85 · AlphaFold monomer V2.0 prediction for interferon-inducible GTPase 1 (Q9QZ85) · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9QZ85
- Elsewhere: RCSB PDB 1TPZ · PDBe 1TPZ · UniProt Q9QZ85
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