MolNFT v1 · #22768 · protein
Ribonuclease from escherichia COLI complexed with its inhibitor protein
1TFO · Colicin D: “Ribonuclease from escherichia COLI complexed with its inhibitor protein”. X-ray diffraction, 3 pockets (best druggability 0.47). MolNFT v1 #22768 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1TFO
- Type
- protein
- Length
- 189 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Colicin D; Colicin D immunity protein
- UniProt
- P17998, P11899
- Pockets
- 3 · best druggability 0.47
Structure
x-ray diffraction · 2 distinct chains · 49% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Colicin D | protein | 103 | 38% helix, 19% strand | P17998 |
| B | Colicin D immunity protein | protein | 86 | 63% helix, 2% strand | P11899 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 154 | 0.47 | 0.77 | 25 | empty |
| 2 | 81 | 0.34 | 0.75 | 15 | empty |
| 3 | 69 | 0.34 | 0.76 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1008 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 1TFO · Ribonuclease from Escherichia coli complexed with its inhibitor protein · the same entry in another collection · chain A against A, TM-score 1.00
- P17998 · AlphaFold monomer V2.0 prediction for colicin-D (P17998) · a predicted model of the same protein · chain A against A, TM-score 0.98
- P11899 · AlphaFold monomer V2.0 prediction for colicin-D immunity protein (P11899) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P17998
- Every structure of UniProt P11899
- Elsewhere: RCSB PDB 1TFO · PDBe 1TFO · UniProt P17998 · UniProt P11899
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