MolNFT v1 · #22757 · protein
Crystal structure of the ligand-binding domain of the estrogen-related receptor gamma in complex with a steroid receptor coactivator-1 peptide
1TFC: “Crystal structure of the ligand-binding domain of the estrogen-related receptor gamma in complex with a…”. X-ray diffraction, 8 pockets (best druggability 0.78). MolNFT v1 #22757 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 1TFC
- Type
- protein
- Length
- 472 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Estrogen-related receptor gamma; Steroid receptor coactivator-1
- UniProt
- P62508, Q15788
- Pockets
- 8 · best druggability 0.78
Structure
x-ray diffraction · 4 distinct chains · 67% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Estrogen-related receptor gamma | protein | 226 | 67% helix, 3% strand | P62508 |
| B | Estrogen-related receptor gamma | protein | 225 | 66% helix, 2% strand | P62508 |
| C | Steroid receptor coactivator-1 | protein | 11 | 73% helix, 0% strand | Q15788 |
| D | Steroid receptor coactivator-1 | protein | 10 | 70% helix, 0% strand | Q15788 |
Pockets
8 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 94 | 0.78 | 0.97 | 18 | empty |
| 2 | 91 | 0.77 | 0.97 | 16 | empty |
| 3 | 525 | 0.70 | 0.80 | 55 | empty |
| 4 | 191 | 0.63 | 0.84 | 25 | empty |
| 5 | 196 | 0.62 | 0.83 | 30 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1305 Ų buried · 13 hydrogen bonds · protein-protein
- A–C · 512 Ų buried · 6 hydrogen bonds · protein-protein
- B–D · 512 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 1TFC · Crystal structure of the ligand-binding domain of the estrogen-related receptor gamma in… · the same entry in another collection · chain A against A, TM-score 1.00
- P62508 · AlphaFold monomer V2.0 prediction for estrogen-related receptor gamma (P62508) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62508
- Every structure of UniProt Q15788
- Elsewhere: RCSB PDB 1TFC · PDBe 1TFC · UniProt P62508 · UniProt Q15788
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