MolNFT v1 · #22635 · protein

Solution structure of a tbp-TAFII230 complex: protein mimicry of the minor groove surface of the tata box unwound by tbp, NMR, 25 structures

1TBA · Transcription initiation factor iid 230K chain: “Solution structure of a tbp-TAFII230 complex: protein mimicry of the minor groove surface of the tata box…”. Solution nmr, 1 pocket (best druggability 0.54). MolNFT v1 #22635 on…

PDB: 1TBA
Type: protein
Length: 247 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcription initiation factor iid 230K chain; Transcription initiation factor tfiid
UniProt: P51123, P13393
Pockets: 1 · best druggability 0.54

Structure

solution nmr · 2 distinct chains · 26% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcription initiation factor iid 230K chain	protein	67	21% helix, 6% strand	P51123
B	Transcription initiation factor tfiid	protein	180	27% helix, 40% strand	P13393

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	94	0.54	0.84	19	empty

Interfaces

1 interface between chains.

A–B · 1602 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

1TBA · Solution structure of a tbp-TAFII230 complex: protein mimicry of the minor groove surface… · the same entry in another collection · chain A against A, TM-score 1.00
P13393 · AlphaFold monomer V2.0 prediction for tata-box-binding protein (P13393) · a predicted model of the same protein · chain B against A, TM-score 0.91
P51123 · AlphaFold monomer V2.0 prediction for transcription initiation factor tfiid subunit 1… · a predicted model of the same protein · chain A against A, TM-score 0.49

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P51123
Every structure of UniProt P13393
Elsewhere: RCSB PDB 1TBA · PDBe 1TBA · UniProt P51123 · UniProt P13393

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