MolNFT v1 · #22615 · protein
Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein
1TAG · Transducin-alpha: “Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein”. X-ray diffraction, 2 ligands (GDP, MG), 1 pocket (best druggability 0.75). MolNFT v1 #22615 on GenesisL1: 3D structure…
- PDB
- 1TAG
- Type
- protein
- Length
- 314 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transducin-alpha
- UniProt
- P04695
- Ligands
- GDP, MG
- Pockets
- 1 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 51% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transducin-alpha | protein | 314 | 51% helix, 13% strand | P04695 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 688 | 0.75 | 0.81 | 82 | MG, GDP |
Compared structures
- 1TAG · Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein · the same entry in another collection · chain A against A, TM-score 1.00
- P04695 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(T) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04695
- Elsewhere: RCSB PDB 1TAG · PDBe 1TAG · UniProt P04695
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