MolNFT v1 · #22445 · protein

Arginase-F2-L-arginine complex

1T5G · Arginase 1: “Arginase-F2-L-arginine complex”. X-ray diffraction, 3 ligands (ARG, MN, F), 13 pockets (best druggability 0.81). MolNFT v1 #22445 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1T5G
Type: protein
Length: 942 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Arginase 1
EC: 3.5.3.1
UniProt: P07824
Ligands: ARG, MN, F
Pockets: 13 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Arginase 1 (EC 3.5.3.1)	protein	314	41% helix, 16% strand	P07824

Ligands and binding sites

ARG · Arginine · ligand · 3 copies · chains A, B, C
MN · Manganese (II) ion · metal · 6 copies · chains A, B, C
F · Fluoride ion · ion · 6 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

13 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	876	0.81	0.83	69	empty
2	449	0.61	0.75	48	empty
3	179	0.58	0.82	29	F, ARG
4	181	0.57	0.81	29	F, ARG
5	178	0.57	0.81	27	F, ARG

Interfaces

3 interfaces between chains.

B–C · 977 Å² buried · 15 hydrogen bonds · protein-protein
A–C · 956 Å² buried · 13 hydrogen bonds · protein-protein
A–B · 928 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

1T5G · Arginase-F2-L-Arginine complex · the same entry in another collection · chain A against A, TM-score 1.00
P07824 · AlphaFold monomer V2.0 prediction for arginase-1 (P07824) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07824
Elsewhere: RCSB PDB 1T5G · PDBe 1T5G · UniProt P07824

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.