MolNFT v1 · #22403 · protein
Structural basis for the autoinhibition and sti-571 inhibition of C- kit tyrosine kinase
1T46 · Homo sapiens V-kit hardy-zuckerman 4 feline sarcoma viral…: “Structural basis for the autoinhibition and sti-571 inhibition of C- kit tyrosine kinase”. X-ray diffraction, 2 ligands (STI, PO4), 1 pocket (best druggability 0.74).…
- PDB
- 1T46
- Type
- protein
- Length
- 297 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Homo sapiens V-kit hardy-zuckerman 4 feline sarcoma viral oncogene homolog
- EC
- 2.7.1.112
- UniProt
- P10721
- Ligands
- STI, PO4
- Pockets
- 1 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Homo sapiens V-kit hardy-zuckerman 4 feline sarcoma viral oncogene homolog (EC 2.7.1.112) | protein | 297 | 39% helix, 18% strand | P10721 |
Ligands and binding sites
- STI · 4-(4-methyl-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide · ligand · chains A
- PO4 · Phosphate ion · ion · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 727 | 0.74 | 0.79 | 64 | STI |
Compared structures
- 1T46 · Structural basis for the autoinhibition and sti-571 inhibition of C-kit tyrosine kinase · the same entry in another collection · chain A against A, TM-score 1.00
- P10721 · AlphaFold monomer V2.0 prediction for MAST/STEM cell growth factor receptor kit (P10721) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10721
- Elsewhere: RCSB PDB 1T46 · PDBe 1T46 · UniProt P10721
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