MolNFT v1 · #22391 · protein

Structure of formylglycinamide synthetase

1T3T · Phosphoribosylformylglycinamidine synthase: “Structure of formylglycinamide synthetase”. X-ray diffraction, 3 ligands (ADP, MG, SO4), 8 pockets (best druggability 0.86). MolNFT v1 #22391 on GenesisL1: 3D structure, binding sites and…

PDB: 1T3T
Type: protein
Length: 1,284 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Phosphoribosylformylglycinamidine synthase
EC: 6.3.5.3
UniProt: P74881
Ligands: ADP, MG, SO4
Pockets: 8 · best druggability 0.86

Structure

x-ray diffraction · 1 distinct chain · 35% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Phosphoribosylformylglycinamidine synthase (EC 6.3.5.3)	protein	1284	35% helix, 27% strand	P74881

Ligands and binding sites

ADP · Adenosine-5'-diphosphate · ligand · chains A
MG · Magnesium ion · metal · 3 copies · chains A
SO4 · Sulfate ion · ion · 6 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	302	0.86	0.96	46	MG, ADP
2	1020	0.83	0.84	103	empty
3	292	0.79	0.91	39	empty
4	115	0.79	0.98	30	empty
5	1037	0.78	0.80	90	SO4

Modifications

Observed in the structure: 1 modified (nonstandard).

Compared structures

1T3T · Structure of Formylglycinamide synthetase · the same entry in another collection · chain A against A, TM-score 1.00
P74881 · AlphaFold monomer V2.0 prediction for phosphoribosylformylglycinamidine synthase (P74881) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P74881
Elsewhere: RCSB PDB 1T3T · PDBe 1T3T · UniProt P74881

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