UniProt P74881
Phosphoribosylformylglycinamidine synthase (P74881)
Phosphoribosylformylglycinamidine synthase (UniProt P74881), EC 6.3.5.3: 24 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 48 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P74881
- Protein
- Phosphoribosylformylglycinamidine synthase
- EC
- 6.3.5.3
- Experimental structures
- 24
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 48 · 5 records with a druggable one
Structures
25 records of P74881 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1T3T | Structure of Formylglycinamide synthetase | x-ray diffraction | A | MG, SO4, ADP | 8 (best 0.86) |
| 1T3T | Structure of formylglycinamide synthetase | x-ray diffraction | A | — | — |
| 3UGJ | Formyl Glycinamide ribonucletide amidotransferase from Salmonella Typhimurum: Role of the ATP… | x-ray diffraction | A | — | — |
| 3UGJ | Formyl glycinamide ribonucletide amidotransferase from salmonella typhimurum: role of the ATP… | x-ray diffraction | A | — | — |
| 3UJN | Formyl Glycinamide Ribonucleotide Amidotransferase from Salmonella Typhimurium : Role of the ATP… | x-ray diffraction | A | — | — |
| 3UJN | Formyl glycinamide ribonucleotide amidotransferase from salmonella typhimurium : role of the ATP… | x-ray diffraction | A | — | — |
| 3UMM | Formylglycinamide ribonucleotide amidotransferase from Salmonella typhimurium: Role of the ATP… | x-ray diffraction | A | — | — |
| 3UMM | Formylglycinamide ribonucleotide amidotransferase from salmonella typhimurium: role of the ATP… | x-ray diffraction | A | — | — |
| 4L78 | Xenon Trapping and Statistical Coupling Analysis Uncover Regions Important for Structure and… | x-ray diffraction | A | — | — |
| 4L78 | Xenon trapping and statistical coupling analysis uncover regions important for structure and… | x-ray diffraction | A | — | — |
| 4LGY | Importance of Hydrophobic Cavities in Allosteric Regulation of Formylglycinamide Synthetase… | x-ray diffraction | A | — | — |
| 4LGY | Importance of hydrophobic cavities in allosteric regulation of formylglycinamide synthetase… | x-ray diffraction | A | — | — |
| 4MGH | Importance of Hydrophobic Cavities in Allosteric Regulation of Formylglycinamide Synthetase… | x-ray diffraction | A | — | — |
| 4MGH | Importance of hydrophobic cavities in allosteric regulation of formylglycinamide synthetase… | x-ray diffraction | A | — | — |
| 4R7G | Determination of the formylglycinamide ribonucleotide amidotransferase ammonia pathway by combining… | x-ray diffraction | A | — | — |
| 4R7G | Determination of the formylglycinamide ribonucleotide amidotransferase ammonia pathway by combining… | x-ray diffraction | A | — | — |
| 6LYK | Crystal Structure of R1263A mutant of Formylglycinamidine Synthetase | x-ray diffraction | A | ADP, GLN, MG, SO4 | 10 (best 0.86) |
| 6LYK | Crystal structure of R1263A mutant of formylglycinamidine synthetase | x-ray diffraction | A | ADP, MG, SO4 | — |
| 6LYL | Crystal structure of S1052D mutant of Formylglycinamidine synthetase | x-ray diffraction | A | SO4, MG, ADP | 9 (best 0.85) |
| 6LYL | Crystal structure of S1052D mutant of formylglycinamidine synthetase | x-ray diffraction | A | SO4, MG, ADP | — |
| 6LYM | Crystal structure of D657A mutant of formylglycinamidine synthetase | x-ray diffraction | A | ADP, MG, SO4 | 11 (best 0.85) |
| 6LYM | Crystal structure of D657A mutant of formylglycinamidine synthetase | x-ray diffraction | A | ADP, MG, SO4 | — |
| 6LYO | Crystal Structure of H296A mutant of Formylglycinamidine Synthetase | x-ray diffraction | A | ADP, SO4, MG | — |
| 6LYO | Crystal structure of H296A mutant of formylglycinamidine synthetase | x-ray diffraction | A | ADP, SO4, MG | — |
| P74881 | AlphaFold monomer V2.0 prediction for phosphoribosylformylglycinamidine synthase (P74881) | predicted | A | — | 10 (best 0.86) |
Ligands
Experiment against prediction
- 6LYM chain A against the predicted model P74881: TM-score 1.00, RMSD 0.28 Å
- 6LYM chain A against the predicted model P74881: TM-score 1.00, RMSD 0.28 Å
- 1T3T chain A against the predicted model P74881: TM-score 0.99, RMSD 0.22 Å
- 1T3T chain A against the predicted model P74881: TM-score 0.99, RMSD 0.22 Å
- 4L78 chain A against the predicted model P74881: TM-score 0.99, RMSD 0.23 Å
- 4L78 chain A against the predicted model P74881: TM-score 0.99, RMSD 0.23 Å
- 3UGJ chain A against the predicted model P74881: TM-score 0.99, RMSD 0.24 Å
- 3UGJ chain A against the predicted model P74881: TM-score 0.99, RMSD 0.24 Å
- 4MGH chain A against the predicted model P74881: TM-score 0.99, RMSD 0.26 Å
- 4MGH chain A against the predicted model P74881: TM-score 0.99, RMSD 0.26 Å
Elsewhere
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