MolNFT v1 · #22153 · protein
Core-streptavidin mutant D128A at pH 4.5
1SWS · Protein (streptavidin): “Core-streptavidin mutant D128A at pH 4.5”. X-ray diffraction, 4 pockets (best druggability 0.64). MolNFT v1 #22153 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1SWS
- Type
- protein
- Length
- 456 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (streptavidin)
- UniProt
- P22629
- Pockets
- 4 · best druggability 0.64
Structure
x-ray diffraction · 4 distinct chains · 7% helix, 59% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein (streptavidin) | protein | 114 | 8% helix, 58% strand | P22629 |
| B | Protein (streptavidin) | protein | 117 | 8% helix, 59% strand | P22629 |
| C | Protein (streptavidin) | protein | 113 | 5% helix, 60% strand | P22629 |
| D | Protein (streptavidin) | protein | 112 | 5% helix, 60% strand | P22629 |
Pockets
4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 379 | 0.64 | 0.79 | 37 | empty |
| 2 | 377 | 0.64 | 0.79 | 39 | empty |
| 3 | 364 | 0.62 | 0.78 | 39 | empty |
| 4 | 361 | 0.62 | 0.78 | 42 | empty |
Interfaces
6 interfaces between chains.
- C–D · 1636 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 1589 Ų buried · 21 hydrogen bonds · protein-protein
- A–D · 398 Ų buried · 3 hydrogen bonds · protein-protein
- B–C · 359 Ų buried · 2 hydrogen bonds · protein-protein
- B–D · 196 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 1SWS · Core-streptavidin mutant D128A at pH 4.5 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22629
- Elsewhere: RCSB PDB 1SWS · PDBe 1SWS · UniProt P22629
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